MOL PUBLICATIONS
2007
1. Advani A, Kelly DJ, Advani SL, Cox AJ, Thai K, Zhang Y, White KE, Gow RM, Marshall SM, Steer BM, Marsden PA, Rakoczy E, Gilbert RE. Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions. Proc Natl Acad Sci USA 2007 104(36):14448-14453
2. Chan E, Amon M, Marano RJ, Wimmer N, Kearns PS, Manolios N, Rakoczy PE, Toth I. Novel cationic lipophilic peptides for oligodeoxynucleotide delivery. Bioorganic Medical Chemistry 2007 15:4091-4098
2006
1. van Eeden PE., Tee L., Shen W-Y., Lukehurst S., Lai C-M., Rakoczy PE., Beazley LD., Dunlop SA. Characterisation of a model for retinal neovascularisation: VEGF model characterisation In Retinal Degenerative Diseases (JG Hollyfield, RE Anderson, MM La Vail, Eds). Springer: New York. 2006 572:163-172.
2. Ghassemifar R., Lai C-M., Rakoczy PE. Regulation of tight junctions in cultured retinal pigment epithelial cells and in VEGF overexpressing transgenic mouse retinas. In Retinal Degenerative Diseases (JG Hollyfield, RE Anderson, MM La Vail, Eds). Springer: New York. 2006 572: 172-185.
3. Shen W-Y., Lai YKY., Lai C-M., Binz N., Dunlop SA., Rakoczy EP. Pathological heterogeneity of vasoproliferative retinopathy in transgenic mice overexpressing vascular endothelial growth factor in photoreceptors. In Retinal Degenerative Diseases (JG Hollyfield, RE Anderson, MM La Vail, Eds). Springer: New York. 2006 572:187- 193.
4. Graham C., Binz N., Shen W-Y., Rakoczy PE. Laser Photocoagulation: Ocular research and therapy. In Retinal Degenerative Diseases (JG Hollyfield, RE Anderson, MM La Vail, Eds). Springer: New York. 2006 572:195-207.
5. Stoddart CW, Yu MJT, Martin-Iverson MT, Daniels DM, Lai C-M, Barnett NL. Redmond TM, Narfstrom K, Rakoczy PE. Assessing the efficacy of gene therapy in RPE65-/- mice using photoentrainment of circadian rhythm. In Retinal Degenerative Diseases (JG Hollyfield, RE Anderson, MM La Vail, Eds). Springer: New York. 2006 572:239-245.
6. Sutanto E, Zhang D, Lai YKY, Shen W-Y, Rakoczy PE. Potential use of cellular promoter(s) to target RPE in AAV-Mediated delivery. In Retinal Degenerative Diseases (JG Hollyfield, RE Anderson, MM La Vail, Eds). Springer: New York. 572:267-273.
7. Marano RJ., Rakoczy PE. Controlling vascular endothelial growth factor: Therapies for ocular disease associated with neovascularization. In Retinal Degenerative Diseases (JG Hollyfield, RE Anderson, MM La Vail, Eds). Springer: New York. 2006 572:303-307.
8. Hall C., Kicic A., Lai C-M., Rakoczy PE., Using stem cells to repair the degenerate retina. Rd204 Proceedings Chapter In Retinal Degenerative Diseases (JG Hollyfield, RE Anderson, MM La Vail, Eds). Springer: New York. 2006 572:381-388.
9. Marano RJ, Rakoczy PE. Treatments for choroidal and retinal neovascularization: a focus on oligonucleotide therapy and delivery for the regulation of gene function. Clin Experiment Ophthalmol. 2006 Feb;33(1):81-9. Review.
10. Rakoczy PE, Yu M, Nusinowitz S, Chang B, Heckenlively R. Mouse models of age-related macula degeneration. Exp Eye Res 2006 May:82(5):741-752.
11. Shen WY, Lai CM, Graham C, Binz N, Lai Y.K.Y, Eade J, Guidolin D, Ribatti D, Dunlop SA, Rakoczy PE. Long-term global retinal microvascular changes in a vascular endothelial growth factor mouse model. Diabetologia 2006 49 (7): 1690-1701.
12. Van Eeden PE, Tee LBG, Lukehurst S, Shen WY, Lai CM, Rakoczy EP, Beazley LD, Dunlop SA. 2005. Early changes in a VEGF transgenic mouse model of retinal neovascularisation. IOVS 2006 47: 4638-45.
13. Marano R, Rakoczy PE. An improved method using densitometry for evaluating severity of laser photocoagulation induced CNV. Biotech Histochem. 2006;81(2-3):59-62
2005
1. Marano RJ, Rakoczy PE. Treatments for choroidal and retinal neovascularization: a focus on oligonucleotide therapy and delivery for the regulation of gene function. Clin Exp Ophthalmol. 2005 Feb;33(1):81-9. Review.
2. Kicic A, Hall CM, Shen WY, Rakoczy PE. Are stem cell characteristics altered by disease state? Stem Cells Dev. 2005 Feb;14(1):15-28.
3. Sutanto EN, Zhang D, Lai YK, Shen WY, Rakoczy PE. Development and evaluation of the specificity of a cathepsin D proximal promoter in the eye. Curr Eye Res. 2005 Jan;30(1):53-61.
4. Lai CM, Dunlop SA, May LA, Gorbatov M, Brankov M, Shen WY, Binz N, Lai YK, Graham CE, Barry CJ, Constable IJ, Beazley LD, Rakoczy PE. Generation of transgenic mice with mild and severe retinal neovascularisation. Br J Ophthalmol. 2005 Jul;89(7):911-6.
5. Lai C-M, Shen W-Y, Brankov M, Lai YKY, Barnett N, Lee S-Y, Yeo IYS, Mathur R, Ho JES, Pineda P, Barathi A, Ang C-L, Constable IJ, Rakoczy EP. Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys. Mol Ther 2005 Oct 12(4):659-68.
6. Marano RJ, Toth I, Wimmer N, Brankov M, Rakoczy PE. Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: a long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity. Gene Ther. 2005 Nov;12(21):1544-50.
7. Ghassemifar R., Lai C-M., Rakoczy PE., VEGF differentially regulates transcription and translation of ZO-1a+ and ZO-1a- and mediates trans-epithelial resistance in cultured endothelial and epithelial cells. Cell Tissue Res. Epub 2005 Sep 15 & 2006 Jan;323(1):117-25.
8. Constable IJ, Shen W-Y, Rakoczy E. Emerging biological therapies for age-related macular degeneration. Expert Opin Biol Ther. 2005 Oct;5(10):1373-85.
9. Zhang D, Brankov M, Makhiha MT, Robertson T, Helmerhorst E, Papadimitriou J, Rakoczy PE. Correlation between inactive cathespins D expression and retinal changes in mcd2/mcd2 transgenic mice. IOVS. 2005 Sept; 46(9)3031-38.
10. Binz N, Graham CE, Simpson K, Lai YKY, Shen W-Y, Lai C-M, Speed T, Rakoczy EP. Long-Term effect of therapeutic laser photocoagulation on gene expression in the eye. The FASEB Journal Online 2005 Dec 10.1096/fj.05-3890fje.
11. Rodger J, Symonds ACE, Springbett J, Shen WY, Rakoczy EP, Beazley LD, Dunlop SA. Eph/ephrin expression in the adult rat retina and superior colliculus following localised unilateral retinal lesions: localised and transneuronal upregulation. Eur J Neurosci. 2005; 22(8):1840-52.
12. Narfstrom K, Vaegan, Katz M, Bragadottir R, Rakoczy E, Seeliger M. Assessment of Structure and function over a 3 year period after Gene Transfer in RPE65-/- dogs. Doc Ophthalmol 2005 Jul;111(1):39-48.
13. Narfström K, Katz ML, Bragadottir R, Ford MM, Redmond TM, Lai C-M, Yu MJY, Brankov M, Barnett NL, Moore SR, Stoddard SW, Martin-Iverson, M.T, Rakoczy PE. Partial recovery of retinal function and structure in RPE65-/- mice and dogs following rAAV-mediated gene therapy. Trends in Gene Therapy Research, Nova Science Publishers, Inc. 2005; 129-45
2004
1. Shen WY, Lai YK, Lai CM, Rakoczy PE. Impurity of recombinant adeno-associated virus type 2 affects the transduction characteristics following subretinal injection in the rat. Vision Res. 2004 Feb;44(4):339-48.
2. Shen WY, Lee SY, Yeo I, Lai CM, Mathur R, Tan D, Constable IJ, Rakoczy PE. Predilection of the macular region to high incidence of choroidal neovascularization after intense laser photocoagulation in the monkey. Arch Ophthalmol. 2004 Mar;122(3):353-60.
3. Zhang D, Sutanto EN, Rakoczy PE. Concurrent enhancement of transcriptional activity and specificity of a retinal pigment epithelial cell-preferential promoter. Mol Vis. 2004 Mar;10:208-14.
4. Lai CM, Yu MJ, Brankov M, Barnett NL, Zhou X, Redmond TM, Narfstrom K, Rakoczy PE. Recombinant adeno-associated virus type 2-mediated gene delivery into the Rpe65-/- knockout mouse eye results in limited rescue. Genet Vaccines Ther. 2004 Apr 27;2(1):3.
5. Marano RJ, Brankov M, Rakoczy PE. Discovery of a novel control element within the 5'-untranslated region of the vascular endothelial growth factor. Regulation of expression using sense oligonucleotides. J Biol Chem. 2004 Sep 3;279(36):37808-14.
6. Marano RJ, Wimmer N, Kearns PS, Thomas BG, Toth I, Brankov M, Rakoczy PE. Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide. Exp Eye Res. 2004 Oct;79(4):525-35.
2003
1. Narfstrom K, Katz ML, Ford M, Redmond TM, Rakoczy E, Bragadottir R. In vivo gene therapy in young and adult RPE65-/- dogs produces long-term visual improvement. J Hered. 2003 Jan-Feb;94(1):31-7.
2. Kicic A, Shanley AC, Hall CM, Rakoczy PE. Marrow stromal cells (MSC): a species comparison. Adv Exp Med Biol. 2003;533:407-14.
3. Narfstrom K, Bragadottir R, Redmond TM, Rakoczy PE, van Veen T, Bruun A. Functional and structural evaluation after AAV.RPE65 gene transfer in the canine model of Leber's congenital amaurosis. Adv Exp Med Biol. 2003;533:423-30.
4. Rakoczy PE, Lai CM, Yu MJ, Daniels DM, Brankov M, Rae BC, Stoddart CW, Barnett NL, Martin-Iverson MT, Redmond TM, Narfstrom K, Zhou X, Constable IJ. Assessment of rAAV-mediated gene therapy in the Rpe65-/- mouse. Adv Exp Med Biol. 2003;533:431-8.
5. Rakoczy PE, Brankov M, Fonceca A, Zaknich T, Rae BC, Lai CM. Enhanced recombinant adeno-associated virus-mediated vascular endothelial growth factor expression in the adult mouse retina: a potential model for diabetic retinopathy. Diabetes. 2003 Mar;52(3):857-63.
6. Wilson AS, Hobbs BG, Shen WY, Speed TP, Schmidt U, Begley CG, Rakoczy PE. Argon laser photocoagulation-induced modification of gene expression in the retina. Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1426-34.
7. Narfstrom K, Katz ML, Bragadottir R, Seeliger M, Boulanger A, Redmond TM, Caro L, Lai CM, Rakoczy PE. Functional and structural recovery of the retina after gene therapy in the RPE65 null mutation dog. Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1663-72.
8. Shen WY, Lai CM, Lai YK, Zhang D, Zaknich T, Sutanto EN, Constable IJ, Rakoczy PE. Practical considerations of recombinant adeno-associated virus-mediated gene transfer for treatment of retinal degenerations. J Gene Med. 2003 Jul;5(7):576-87.
9. Ford M, Bragadottir R, Rakoczy PE, Narfstrom K. Gene transfer in the RPE65 null mutation dog: relationship between construct volume, visual behavior and electroretinographic (ERG) results. Doc Ophthalmol. 2003 Jul;107(1):79-86.
10. Kicic A, Shen WY, Wilson AS, Constable IJ, Robertson T, Rakoczy PE. Differentiation of marrow stromal cells into photoreceptors in the rat eye.
J Neurosci. 2003 Aug 27;23(21):7742-9.
11. Daniels DM, Stoddart CW, Martin-Iverson MT, Lai CM, Redmond TM, Rakoczy PE. Entrainment of circadian rhythm to a photoperiod reversal shows retinal dystrophy in RPE65(-/-) mice. Physiol Behav. 2003 Sep;79(4-5):701-11.
12. Daniels DM, Shen WY, Constable IJ, Rakoczy PE. Quantitative model demonstrating that recombinant adeno-associated virus and green fluorescent protein are non-toxic to the rat retina. Clin Experiment Ophthalmol. 2003 Oct;31(5):439-44.
13. May LA, Lai CM, Rakoczy PE. In vitro comparison studies of truncated rhodopsin promoter fragments from various species in human cell lines.
Clin Experiment Ophthalmol. 2003 Oct;31(5):445-50.
14. Rakoczy PE, Shen WY, Barry CJ. Eye Diseases. In Molecular Pathomechanism and New Trends in Drug Research. 2003 Taylor & Francis; London.
15. Rakoczy PE, Lai CM, Yu MJ, Daniels DM, Brankov M, Rae BC, Stoddart CW, Barnett NL, Martin-Iverson MT, Redmond TM, Narfstrom K, Zhou X, Constable IJ. Assessment of rAAV-mediated gene therapy in the Rpe65-/- mouse. In Retinal Degeneration Mechanisms and Experimental Therapy (JG Hollyfield, RE Anderson Mm LaVail Eds). 2003 Luwer Academic / Plenum Publishers; New York: USA. 533:431-438
16. Kicic A, Shanley AC, Hall CM, Rakoczy PE. Marrow stromal cells (MSC): a species comparison. In Retinal Degeneration Mechanisms and Experimental Therapy (JG Hollyfield, RE Anderson Mm LaVail Eds). 2003 Luwer Academic / Plenum Publishers; New York: USA. 533:407-414.
17. Lai YK, Sharma S, Lai CM, Brankov M, Constable IJ, Rakoczy PE. Virus-mediated secretion gene therapy - A potential treatment for ocular neovascularization. In Retinal Degeneration Mechanisms and Experimental Therapy (JG Hollyfield, RE Anderson Mm LaVail Eds). 2003 Luwer Academic / Plenum Publishers; New York: USA. 533:447-453.
18. Narfström K, Bragadottir R, Redmond TM, Rakoczy PE, van Veen T, Bruun A. Functional and structural evaluation after AAV.RPE65 gene transfer in the canine model of Leber's congenital amaurosis. In Retinal Degeneration Mechanisms and Experimental Therapy (JG Hollyfield, RE Anderson Mm LaVail Eds). 2003 Luwer Academic / Plenum Publishers; New York: USA. 533:423-430.
2002
1. Chirila TV, Rakoczy PE, Garrett KL, Lou X, Constable IJ. The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides. Biomaterials. 2002 Jan;23(2):321-42.
2. Zhang D, Lai MC, Constable IJ, Rakoczy PE. A model for a blinding eye disease of the aged. Biogerontology. 2002;3(1-2):61-6.
3. Shen WY, Garrett KL, Wang CG, Zhang K, Ma ZZ, Constable IJ, Rakoczy PE. Preclinical evaluation of a phosphorothioate oligonucleotide in the retina of rhesus monkey. Lab Invest. 2002 Feb;82(2):167-82.
4. Lai YK, Shen WY, Brankov M, Lai CM, Constable IJ, Rakoczy PE. Potential long-term inhibition of ocular neovascularisation by recombinant adeno-associated virus-mediated secretion gene therapy. Gene Ther. 2002 Jun;9(12):804-13.
5. Wilson AS, Hobbs BG, Speed TP, Rakoczy PE. The microarray: potential applications for ophthalmic research. Mol Vis. 2002 Jul 17;8:259-70.
6. Wimmer N, Marano RJ, Kearns PS, Rakoczy EP, Toth I. Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2635-7.
7. Smythe GM, Lai MC, Grounds MD, Rakoczy PE. Adeno-associated virus-mediated vascular endothelial growth factor gene therapy in skeletal muscle before transplantation promotes revascularization of regenerating muscle. Tissue Eng. 2002 Oct;8(5):879-91.
8. Rakoczy PE, Zhang D, Robertson T, Barnett NL, Papadimitriou J, Constable IJ, Lai CM. Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model. Am J Pathol. 2002 Oct;161(4):1515-24.
9. Lai CM, Spilsbury K, Brankov M, Zaknich T, Rakoczy PE. Inhibition of corneal neovascularization by recombinant adenovirus mediated antisense VEGF RNA. Exp Eye Res. 2002 Dec;75(6):625-34.
10. Lai CM, Lai YK, Rakoczy PE. Adenovirus and adeno-associated virus vectors. DNA Cell Biol. 2002 Dec;21(12):895-913.
11. Zaknich TS, Shen WY, Barry CH, Brankov M, Rakoczy E. Simple modification of clinical cameras for retinal photography and angiography in small laboratory animals. J Ophthalmic Photogr. 2002 24(2):66-69.
2001
1. Chavand O, Spilsbury K, Rakoczy PE. Addition of a c-myc epitope tag within the VEGF protein does not affect in vitro biological activity. Biochem Cell Biol. 2001;79(1):107-12.
2. Lou X, Garrett KL, Rakoczy PE, Chirila TV. Synthetic hydrogels as carriers in antisense therapy: preliminary evaluation of an oligodeoxynucleotide covalent conjugate with a copolymer of 1-vinyl-2-pyrrolidinone and 2-hydroxyethyl methacrylate. J Biomater Appl. 2001 Apr;15(4):307-20.
3. Garrett KL, Shen WY, Rakoczy PE. In vivo use of oligonucleotides to inhibit choroidal neovascularisation in the eye. J Gene Med. 2001 Jul-Aug;3(4):373-83.
4. Lai CM, Brankov M, Zaknich T, Lai YK, Shen WY, Constable IJ, Kovesdi I, Rakoczy PE. Inhibition of angiogenesis by adenovirus-mediated sFlt-1 expression in a rat model of corneal neovascularization. Hum Gene Ther. 2001 Jul 1;12(10):1299-310.
5. Shen WY, Lai MC, Beilby J, Barnett NL, Liu J, Constable IJ, Rakoczy PE. Combined effect of cyclosporine and sirolimus on improving the longevity of recombinant adenovirus-mediated transgene expression in the retina. Arch Ophthalmol. 2001 Jul;119(7):1033-43.
6. Lai YK, Rolling F, Baker E, Rakoczy PE. Kinetics of efficient recombinant adeno-associated virus transduction in retinal pigment epithelial cells. Exp Cell Res. 2001 Jul 15;267(2):184-92.
7. Shen WY, Rakoczy PE. Uptake dynamics and retinal tolerance of phosphorothioate oligonucleotide and its direct delivery into the site of choroidal neovascularization through subretinal administration in the rat. Antisense Nucleic Acid Drug Dev. 2001 Aug;11(4):257-64.
8. Kicic A, Shen W, Rakoczy PE. The potential of marrow stromal cells in stem cell therapy. Eye. 2001 Dec;15(Pt 6):695-707.
9. Lai CM. Basic molecular biology techniques. In Vision Research Protocols. (PE Rakoczy Ed). 2001 Human Press; Totowa: USA.
10. Rakoczy PE. Antisense DNA Technology. In Vision Research Protocols. (PE Rakoczy Ed). 2001 Human Press; Totowa: USA.
2000
1. Yu MJ, Shen WY, Lai MC, Constable IJ, Papadimitriou JM, Rakoczy PE. The role of vascular endothelial growth factor (VEGF) in abnormal vascular changes in the adult rat eye. Growth Factors. 2000;17(4):301-12.
2. Rakoczy PE, Shen WY, Lai M, Rolling F, Constable IJ. Development of gene therapy based strategies for the treatment of eye diseases. Drug Devel Res. 1999;46(3-4):277-85.
3. Hjelmeland LM, Cristofolo VJ, Funk W, Rakoczy PE, Senescence of the retinal pigment epithelium. In “Pathogenesis and treatment of ARMD, current knowledge and future research.”
4. Rakoczy P, Shen WY, Spilsbury K, Yu M, Barry C, Constable IJ. Development of rat models for choroidal neovascularisation (CNV). A comparison between laser and recombinant adenovirus induced CNV. In Retinal Degeneration Disease and Experimental Therapy. (JG Hollyfields, RE Anderson, MM LaVail, Eds). 1999 Plenum Publishing Corp; New York.
5. Lai CM, Shen WY, Constable I, Rakoczy PE. The use of adenovirus-mediated gene transfer to develop a rat model for photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2000 Feb;41(2):580-4.
6. Shen WY, Constable IJ, Chelva E, Rakoczy PE. Inhibition of diclofenac formulated in hyaluronan on angiogenesis in vitro and its intraocular tolerance in the rabbit eye. Graefes Arch Clin Exp Ophthalmol. 2000 Mar;238(3):273-82.
7. Zhang D, Lai MC, Constable IJ, Rakoczy PE. A novel immunoassay for the evaluation of rod outer segment digestion in cultured retinal pigment epithelial cells. Clin Experiment Ophthalmol. 2000 Jun;28(3):216-9.
8. Spilsbury K, Garrett KL, Shen WY, Constable IJ, Rakoczy PE. Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization. Am J Pathol. 2000 Jul;157(1):135-44. Erratum in: Am J Pathol 2000 Oct;157(4):1413.
9. Kvanta A, Shen WY, Sarman S, Seregard S, Steen B, Rakoczy E. Matrix metalloproteinase (MMP) expression in experimental choroidal neovascularization. Curr Eye Res. 2000 Sep;21(3):684-90.
10. Rolling F, Shen WY, Barnett NL, Tabarias H, Kanagasingam Y, Constable I, Rakoczy PE. Long-term real-time monitoring of adeno-associated virus-mediated gene expression in the rat retina. Clin Experiment Ophthalmol. 2000 Oct;28(5):382-6.
11. Lai CM, Robertson T, Papadimitriou J, Shen WY, Daw N, Constable IJ, Rakoczy PE. Controlled production of active cathepsin D in retinal pigment epithelial cells following adenovirus-mediated gene delivery. Mol Ther. 2000 Nov;2(5):476-84.
