In our Retinal Disease Modeling research stream, skin cells from patients with inherited retinal diseases are reprogrammed into induced pluripotent stem cells, then differentiated into retinal organoids and retinal pigment epithelial cells for molecular analysis. Patient-derived retinal cells are used to uncover the pathogenic mechanisms of gene mutations associated with various retinal diseases present in the WARD cohort, including retinitis pigmentosa, Stargardt disease and Usher syndrome. Understanding the molecular pathology of retinal diseases is essential for providing patient prognoses, as well as the identification of new therapeutic strategies for preventing vision loss.
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